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Consider speaking with a dermatologist or skincare specialist for personalised guidance or if you have specific skin concerns

2014 Mar;144(3):252-7

In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years
Metabolic risk factors for PCOS, such as insulin resistance and obesity, play a significant role in the disorder's development and management