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Clinical trials examining both symptom scores and objective measures of esophageal healing would evaluate this potential indication

HSP32, known as heme oxygenase-1 (HO-1), serves as the principal mediator of celastrols protective effects
Expert Opinion on Pharmacotherapy

2.1.3 Collapse of antioxidant defense mechanisms The antioxidant defense System in cells is critically dependent on glutathione peroxidase 4 (GPX4), a crucial metabolic enzyme that uses glutathione (GSH) to convert lipid peroxides into non-toxic alcohols, thereby minimizing harmful lipid peroxidation and safeguarding cells from ferroptosis
