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A., Steinhilber, D., Sgambato, A., & Patrignani, P

The continuous turnover of synovial fluid leads to a short residence time for the administered peptides in the joint space, whereas the dense, negatively charged cartilage matrix impedes their diffusive transport

As a result, the combined treatment demonstrates a markedly improved antagonistic effect against I/R-induced oxidative stress (Huang et al., 2014)

However, it is rendered ineffective when evaluating possible toxicity due to multiple ingestions over time, when time of ingestion is unknown, or when altered metabolism occurs
