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Follow these easy steps for the best results: Wear the Patch ON for 12 Hours Apply the patch to clean, dry skin

Its levels decline significantly as we age
UBB+1, which arises through a frame-shift mutation in the ubiquitin gene that adds 19 amino acids to the C-terminus of ubiquitin, inhibits proteasomal function and is associated with increased neurofibrillary tangles in patients with AD, Picks disease and Downs syndrome

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