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The skin is chronically exposed to both endogenous and environmental pro-oxidants leading to the production of ROS.[] ROS leads to lipid peroxidation, which is considered as the hallmark of oxidative stress in body.[] Malondialdehyde (MDA) is considered as the end product of lipid peroxidation and MDA levels is directly proportional to the oxidative stress.[] The most important antioxidants present in human body include superoxide dismutase, glutathione peroxidase, and catalase.[] Glutathione which is considered a master antioxidant can help keep the balance between the oxidant and antioxidant system in the body and prove to be an effective therapy but studies proving its efficacy are limited

vtc2 mutants with ~ 20% of wild type ascorbate grow nearly as well as WT [206] although the widely-used vtc2-1 allele is small [205], [207]

Redox Biol 24:101223 Janbaz KH, Saeed SA, Gilani AH (2002) Protective effect of rutin on Paracetamol-and CCl4-induced hepatotoxicity in rodents

Based on thirty years of interviews, this masterful biography is filled with insights into the life and work of this complex, fascinating man.