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In particular, we demonstrated that decrement in GSH level, induced pharmacologically by treatment with buthionine sulfoximine (BSO) or metabolically by fasting, resulted in increased NO bioavailability at the muscle level, a condition that could be detrimental [44]

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JJ Dugoua is a naturopathic doctor in Toronto and has a PhD in Pharmaceutical Sciences

Disulfide linkers rely on the intracellular reductive environment to trigger payload release
