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The most common technique used is a transforaminal approach to the epidural space in which the injection is placed next to nerve as it exits the spinal canal through a side door (foramen)
MCP-1 is a chemo-attractant that recruits macrophages to the PC, thus decreasing levels of MCP-1 could reduce the secretion of pro-inflammatory cytokines and pain-inducing prostaglandins which are secreted by macrophages [110,111]
hence, it may be prudent to monitor more closely the aminotransferase levels in this group during omaveloxolone treatment
