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Blunted or impeded therapeutic response to vitamin B12 may be due to such conditions as infection, uremia, drugs having bone marrow suppressant properties such as chloramphenicol, and concurrent iron or folic acid deficiency

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Independent t-test/ANOVA with post-hoc Bonferroni correction was used to compare metabolite quantities between groups

(PubMed) Quadri P, Fragiacomo C, Pezzati R, et al
