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Low tumor oxygen and low blood oxygen enhance tumor growth and create resistance to treatment as described in the section The Five Rs of Radiobiology (Gaspar 2015)

Leukocyte adhesion assay Human leukocytes were isolated from peripheral blood of volunteers (under written consent) by using Ficoll-Paque Plus (Amersham Pharmacia Biotech, NJ, USA) according to manufactures guidelines and incubated with 2'7'-bis(carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester (2 M

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