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In another experiment, mice with cAtg3-KO-induced cardiac dysfunction were treated with 5-amino-1-MQ

Certain alkaloids and their derivatives ameliorate neurodegenerative diseases through autophagy activation

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Also, despite the presence of major structural and functional abnormalities of brain vessels in Notch3 KO mice neither overt brain lesions nor clinical manifestations have been reported in these mice, a finding which is in striking contrast with the extreme severity of the human disease (236)
