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doi: 10.1016/j.mpmed.2011.08.006

Pharmacokinetic investigations with varying doses via the enema route could provide a more comprehensive understanding of its bioavailability and therapeutic potential

A second signal that activates AMPK is calcium importmediated activation of calcineurin, and the downstream activation of calcium/calmodulin-activated kinase kinase (CAMKK) (58)
