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In the metabolism of aromatic amines, N-hydroxy aromatic amine metabolites generated in the liver enter the bladder via urine and are further acetylated by NAT1 in the bladder epithelial cells, resulting in the production of highly reactive intermediates

According to in vivo microdialysis of the rat hippocampal region conducted after intravenous administration of these fundamental flavanol monomer units, catechins and epicatechins cross the BBB [34]

doi: 10.1016/j.ejphar.2019.172593

However, in ME2 homozygously deleted PDAC cell lines, its isoenzyme ME3 plays the compensatory roles for intracellular NADPH homeostasis