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Notably, our study advances prior knowledge by employing an integrative multi-omics approach coupled with machine learning-based feature prioritization and multi-level experimental validation

Methods Mice Wild-type C57BL/6J (B6) were purchased from Charles River (stock number JAX 000664)

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However, these results were insufficient to confirm the stability of ligandprotein binding and subsequent enzyme activation because docking deals with proteins as rigid molecules and ignore time evolution in ligandprotein interaction
