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There is growing consensus regarding their pathophysiology and management, but more work is needed to elucidate the relationships between irAEs and treatment outcomes, specific biomarkers that clinch an irAE diagnosis, the impact of tailored immunosuppression on ICI outcomes, and the management of steroid-refractory irAEs

Cancer 13 BramantiE.AngeliV.FranziniM.VecoliC.BaldassiniR.PaolicchiA.et al (2009)

Thus, the health-promoting effects of dietary fruits and vegetables likely reflect a complex interaction among many naturally occurring compounds, which has not been duplicated by consumption of isolated antioxidant compounds

Daraee H, Etemadi A, Kouhi M, et al