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Biol Chem 397(5):383400 Mukherjee R et al (2025) Investigating the interplay between the Nrf2/Keap1/HO-1/SIRT-1 pathway and the p75NTR/PI3K/Akt/MAPK cascade in neurological disorders: mechanistic insights and therapeutic innovations
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Notably, exosomes secreted by TAMs in the TME highly express PD-L1 and inhibit CD8 + T cell function through a Rab27a-dependent mechanism, while knockdown of Rab27a in macrophages significantly enhances the efficacy of anti-PD-1 therapy (305)
Vukojevic et al., 2018
