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Previously reported changes in the abundance of this family Prevotellaceae in advanced PD seem to have been expanded upon by Bedarf and associates, who have shown a dramatic decrease in the numbers of Prevotella copri in patients with early-stage PD ( Prevotella produce SCFAs like butyrate, their decrease may affect intestinal barrier function and immune health and thus be involved in the pathogenesis of PD (Hey et al., 2023)