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Mitochondrial Changes in CD8 + Effector T Cells Whereas glycolysis is important for full activation of Te cells, and lack of glycolytic flux can perturb function, mitochondrial morphology changes dynamically during the life of T cells, and these changes are associated with the engagement of distinct metabolic pathways

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There is a lack of available functional spinal MOR due to this downregulation/desensitization, which leads to a lower analgesic effect of intrathecal injection of opioids compared with intraperitoneal injection and failure to reduce allodynia following neuropathy [130,131,132]

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