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Need for Progressive Regulation: Critics suggest the FDAs regulatory processes may not fully accommodate the fast-paced evolution of biomedical research

(2013) used statistical modeling to identify a single change point at which the relation between plasma methylmalonic acid and serum B12 changes slope to differentiate between inadequate and adequate B12 status

It depends on how bad your deficiency is and how you react to treatment

Symptoms that are severe when people first seek help often improve by the time they are next measured, simply because of natural fluctuation, a phenomenon known as regression to the mean