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The Research Units on Pediatric Psychopharmacology (RUPP) Autism Network conducted a randomized, placebo-controlled, 4-week crossover trial of MPH in 72 children ages 5 to 14 years [79]

[DOI] [PubMed] [Google Scholar] 40.DAlbis G., Forte M., Fioriello M.C., Artin A., Montaruli A., Di Grigoli A., Kazakova R., Dimitrova M., Capodiferro S

Published in Pediatric Exercise Science

Of interest, the down-expression of ACC2 results from an epigenetic process linked to histone deacetylation at the ACACB promoter by Sirtuin 1/6 that are activated by high cytosolic NAD + levels associated with enhanced FAO and reduced glucose metabolism