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A later study using lineage-specific fluorescent reporters did not support tumor cells as a source of endothelial cells in glioma, instead demonstrating that glioma cancer stem cells can differentiate into pericytes and that specific depletion of pericytes disrupted tumor vessels and tumor growth [81]
Nevertheless, this field continues to encounter numerous challenges, such as the need to identify safe and effective probiotic strains to ensure that they can significantly reduce TMAO levels
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