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In conclusion, the wheat germ cell-free system proved to be a suitable method for synthesizing the active forms of polyproteins from several orthoflaviviruses

The activated PKC phosphorylates GluA2-C terminus, ultimately leading to the detachment of AMPA receptors from the scaffold protein and its internalization with PICK1 in AP2- and clathrin-dependent manners [65]

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This modification enhances its biological activity, resulting in a higher affinity for the IGF-1 receptor and a lower affinity for IGF-binding proteins compared to endogenous IGF-1