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One study demonstrated increased distal leg IENFD by 1.5 fibres mm 1 in patients with diabetes (without neuropathy) who received a weekly structured and supervised exercise programme, but IENFD was unchanged in patients who received lifestyle counselling (0.1 fibres mm 1

5-(Biotinamido)pentylamine (BP) incorporation assay Purified GST tag and human TG2 were incubated with BP (Pierce), 5 mM 1,4-dithiothreitol (DTT) (Sigma-Aldrich), and CaCl 2 (Sigma-Aldrich)

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The most frequently mutated genesCDKN2A, TP53, KRAS, and SMAD4currently lack viable pharmacological targets, significantly hindering the development of effective treatment options [6]