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Previous studies found that eight weeks of supplementation with 800 mg of Cit per day was required to increase plasma Arg levels and improve FMD [101]

205,206,207 Beyond this, GLP-1 exerts pleiotropic effects on multiple organs, including those involved in appetite control, whereas GIP directly influences metabolic processes in the endocrine pancreas and adipose tissue

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To explore the reasons for this, the investigators found increased fat accumulation in muscle and liver tissue as assessed by 1H NMR spectroscopy and an approximately 40% reduction in mitochondrial oxidative and phosphorylation activity as assessed by in vivo 13C/31P NMR spectroscopy (118)