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In the case of copper, increased toxicity is believed to be linked to a coordinated sequence of events (lysosome rupture and/or the reduction of the GSH/GSSG ratio) that induce significant cytotoxicity(Lovejoy et al
The water-scaled metabolite levels in mmol/kg were computed using the following equations 34,35 : where S GSH and S H2O represent the GSH and water signal integrals, respectively
Interv Neuroradiol
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