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Well, normally this vitamin is absorbed in the gut and so a disruption to normal gut function will reduce the amount of vitamin B12 that's being absorbed by the intestines and that will lead to a depletion of the normal body stores, which will then result in a deficiency in this vitamin within the body as a whole

You lose the potential therapeutic benefits of glycine, specifically the muscle preservation support, sleep quality improvement, and anti-inflammatory effects, and the formulation may have slightly reduced stability compared to one with a dedicated buffering agent

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investigated the direct effects of folic acid on endothelial function in patients with coronary artery disease (CAD) through Flow Mediated Dilatation (FMD) measurement before and after folic acid intake