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Taking into consideration that the intestinal epithelium has a surface area of ~2 10 6 cm 2 (Fasano, 1998), paracellular route corresponds to ~200 to 2000 cm 2

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Thus, although some of the damage in this experimental model of colitis reflects a direct erosive effect of TNBS and ethanol, their combined administration to rats reflects the in vivo operation of the damaging mechanisms elicited by TNBS, namely GSH depletion and ROS generation, indicating that ethanol facilitates the access of TNBS to the cell interior ensuring TNBS-induced GSH depletion and ROS generation

Canaday has now filed a tip with the agency