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Post-mitotic cells, such as neurons, are particularly vulnerable to the accumulation of misfolded proteins during normal aging, concomitant with a decrease in proteasome activity

6 Conclusion OA refers to inflammatory diseases that occur in the joint and surrounding tissues of the human body and are caused by inflammation, degeneration, trauma, or other metabolic factors (Bijlsma et al., 2011)

First, it can serve as a diagnostic test to pinpoint the joint causing the pain
