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This provides the first clinical validation that targeting the oxidative TME can overcome resistance to checkpoint blockade

PMID: 245 TakahashiMCortsJDentRPusztaiLMcArthurHKmmelSet al

This highlights the importance of regenerative strategies to rebuild disrupted networks

Curcumin applied at 200 mg/kg intraperitoneal infusion daily also inhibited the growth, oxidative damage, and mitochondrial accumulation of tumor xenografts in vivo
