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The combination of 1% SDGC with 10% ethanol and 5% NAC with 10% ethanol showed the maximum drug permeation

In a clinical trial designed to evaluate the effects of apple extract (AP) supplements containing PCs on skin pigmentation issues induced by UV exposure in healthy women, participants were randomly assigned to three groups: a low-dose AP group (300 mg/day), a high-dose AP group (600 mg/day), and a placebo group

While a definitive, universally effective therapy remains elusive, ongoing research continues to expand the options available, fostering hope for more effective and personalized care in the future

10.1016/j.bbamcr.2012.03.004 491 WehnA