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NRF2 deficiency replicates transcriptomic changes in alzheimers patients and worsens APP and TAU pathology

Moreover, exosomes from these alcohol-conditioned DCs boost HBV-specific CD8 + and CD4 + T-cell proliferation and effector function in vivo , challenging the notion of alcohol as solely detrimental by revealing context- and dose-dependent immunostimulatory effects ( Collectively, these findings indicate that chronic or high-dose alcohol consumption profoundly impairs antigen presentation, CTL function, and immune-metabolic homeostasis in the liver, thereby promoting viral persistence, immune evasion, and metabolic stress

Studies further indicate that removing potential copper-binding sites on Htt can eliminate coppers pathogenic effect in HD, suggesting that Huntingtons disease is not only a polyglutamine disease but also involves copper-regulated pathogenic mechanisms (131)

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