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In 2023, Zhangs group reported two innovative tumor hypoxia-activated PROTACs 59 and 60 targeting epidermal growth factor receptor 19 deletions (EGFR DEL19 )
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This peripheral deafferentation, which reduces normal signal input to the central auditory system, is the initial driver for a series of subsequent central compensatory changes and remodeling (Auerbach et al., 2014)
