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Description
The overall pattern of deleterious (S908A/T911A + R716A) and neutral or marginally positive (S914A + R206E) mutations aligns with the structural placement of the phosphorylated R-domain

In addition, another study showed approximately 29% of individuals under the age of 18 with cystic fibrosis exhibit diminished levels of vitamin K (189)

Thus, PLC2 appears to function both upstream and downstream of SLP-76

[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Adlouni, A., Ghalim, N., Benslimane, A., Lecerf, J
