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doi: 10.1186/s13036-024-00472-x
Contraction of smooth muscle is mediated by the release of calcium, while relaxing effects are mediated by the generation of cAMP
However, there is good evidence that, although folic acid binds avidly to this receptor in the choroid plexus, it does not cross the opposite, apical membrane to enter the cerebrospinal fluid (CSF) (78)
375 For example, cyclophosphamide, an alkylating agent used in both hematological malignancies and solid tumors, can disrupt the small intestinal epithelium
