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[DOI] [PubMed] [Google Scholar] 73.Nicoletti C
Reduced sirtuin activity in an NAD + -depleted environment contributes, both indirectly via metabolic collapse and augmented fibrotic signaling, as well as by further inducing cellular senescence, to unchecked fibroblast activation and myofibroblast persistence driving intractable fibrosis
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They are most effective when combined with a good diet, a healthy lifestyle, and medical supervision
