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Nrf2 expression is upregulated in tumor infiltrating T cells and induces T cell anergy

Brain-specific endothelial induction of prostaglandin E 2 synthesis enzymes and its temporal relation to fever

In addition to its role in oxidizing macromolecules such as proteins and lipids, H 2 O 2 has also been proposed to function as a signal to induce the expression of genes involved in the senescence process ( Arabidopsis could be induced by ozone (Miller et al., 1999) and the expression of many other SAGs were also induced by ROS ( 2 O 2 treatment in both leaves and roots ( Distinct from the positive role of ROS in senescence, NO can both provoke and impede this process, dependent upon its concentration and subcellular location

Therefore, the effects of these two systems on HIFs and NRF2 signaling systems are complex, implying the presence of a network connecting these two systems