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Similarly, Pfizer/BioNTechs mRNA-1020/1030 vaccines underwent rigorous evaluation in animal models, where they demonstrated an ability to induce durable neutralizing antibody responses against SARS-CoV-2 (Omicron-adapted antigens) and the four influenza strains targeted by the quadrivalent component 53

The rationale for combining the two is pharmacological complementarity

They enhance the expression of the intracellular adhesion molecule-1 on the thyrocytes, which could attract the immunocompetent cells into the thyroid gland