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The binding of different extracellular ligands of angiotensin II type 1 receptor (AT1R) results in distinct GPCR conformations that favor different signaling partners (Gq protein subunit and -arrestins) (Wingler et al

13 For COVID-19 repurposing of an existing clinically approved drug, it is pivotal to demonstrate its antiviral, anti-inflammatory, and related effects against SARS-CoV-2 in cell-based systems in vitro

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Potential areas of interest include improved circulation through development of blood vessels, enhanced repair signaling, support for antioxidant defense systems, and improved structural recovery following skin damage