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19 Importance of the nigrostriatal pathway and implications of its loss As SNpc neurons send long axonal projections to the striatum, the stereotypical neurodegeneration that occurs in PD deprives the striatum of crucial dopaminergic inputs and thereby interrupts important motor feedback pathways

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Results from the present study further corresponded well with this viewpoint in which increment of Fe 2+ expression coincided well with the up-regulation of ATF6, IRE1, PERK, and BAX activities (Figures 5, 6), all are key elements participated in the development of ER stress and apoptosis