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* Correspondence: Rana Al-Sadi, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Similarly, a study based on swimming exercise for a total of four hours showed an increase in NAD + levels, yet also in this case, no measurements of mitochondrial function were performed 309 , reinforcing the need for more exercise-based investigations to further define how NAD + and mitochondrial homeostasis are perturbed and connected during exercise

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