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doi:10.1136/bmjopen-2020-044385

277,278,279 When dysfunctional mitochondria cannot be cleared in time by mitophagy, damaged mitochondria accumulate, which results in insufficient energy supply as well as overproduced ROS, thereby triggering intense oxidative stress and cellular damage

Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8 + T cells