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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Franke LM, Walker WC, Hoke KW, Wares JR

A meta-analysis of global birth prevalence of spina bifida showed that when mandatory fortification was compared to countries with voluntary fortification or no fortification program, there was a 30% reduction in live births with spina bifida, [36] with some countries reporting a greater than 50% reduction

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The MTHFR 677TT genotype has been associated with increased ASD risk, potentially through impaired methylation capacity, elevated homocysteine, and altered neurodevelopmental signaling