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Relapse From Deep Remission After Therapeutic De-escalation in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Single-drug and cross-drug resistance Because of the similar structure and mechanisms of action of the four NAIs, NA mutations leading to NAIs multi-drug resistance are more common than those leading to single drug resistance (Table 3)

pharmaceutically acceptable excipients may include suitable fillers, binders, lubricants, buffers, glidants, and disentegrants known in the art (see, for example, Remington: The Science and Practice of Pharmacy (2012)

Extra care should be provided to patients with PD to minimize the risk of infection