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[DOI] [PubMed] [Google Scholar] 42.Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

Heat exposure Temperatures above 86 degrees Fahrenheit (30 degrees Celsius) accelerate degradation of both the peptide and the B12

Systemic : Inflammation regulation, damage repair, and inter-system communication (e.g., brain, gut, muscles, metabolism)

This is a safer approach because your body's natural feedback system stays intact
