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In another study, the PTGS2 expression modulated esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis (Feng et al., 2021)

The pH optimum for the active saturable transport is 5.56.0, which explains why antacids seem to reduce folate absorption
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doi: 10.3389/fmed.2025.1693643 Received 27 August 2025 Revised 05 December 2025 Accepted 11 December 2025 Published 28 January 2026 Volume 12 - 2025 Edited by Fang Zhong, Icahn School of Medicine at Mount Sinai, United States Reviewed by Hua Miao, Northwest University, China Jinxin Du, Shandong Academy of Medical Sciences (SDAMS), China Updates Copyright 2026 Yu, Liu, Gu, Tang and Li