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The loss in women occurs at a peak rate of 1-3% per month , far exceeding the 1-3% per year that can occur in postmenopausal women who are considered to be losing bone rapidly

This disruption leads to a loss of fibroblast spreading and mechanical force, resulting in an "aging" phenotype [19]

24 Department of Surgery, McGill University, Montreal, QC, Canada

A significant body of evidence has highlighted the role of cytokines in the regulation of various tight junction proteins in a multitude of pathological conditions
