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doi: 10.4161/cc.27476
Journal of neuroinflammation 10 , 142, (2013)
Melanotan I, being more selective for MC1R, remains more skin focused in its pharmacology and is typically administered as a slow-release subcutaneous implant in its approved medical form, smoothing out plasma concentrations and reducing peaks that can amplify side effects
All vasoconstrictor drugs can reduce splanchnic blood flow (especially phenylephrine), and could aggravate pancreatic necrosis, so careful titration of infusion rates (and avoiding phenylephrine) is advised
