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The formulation is effective at 1.5 mg/kg, representing 3 to 66 times lower dose than conventional administration, demonstrating enhanced therapeutic availability and cardioprotection ( RGD-modified and PEGylated solid lipid nanoparticles encapsulating puerarin (RGD/PEG-PUE-SLN), prepared by a modified solvent evaporation method, exhibit a particle size of 110.5 nm, a PDI of 0.23, a negative zeta potential (26.2 mV), high encapsulation efficiency (85.7%), a DL of 16.5%, and sustained drug release

Cell signaling is crucial for communication between organs and the nervous system, as well as between the brain and endocrine system

Biochem Biophys Res Commun 71(4):952958 Maiorino M, Bosello V, Cozza G, Roveri A, Toppo S, Ursini F

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