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A deficiency in B12 is one of the most common causes of peripheral neuropathy, a condition characterised by tingling, numbness, burning sensations, or weakness in the hands and feet

doi: 10.1159/000496603 42

This distribution aligns with prior reports showing that cortical demyelination is less severe and occurs with delayed kinetics ( As expected, the expression of classical pro-inflammatory cytokines (TNF-, IL-6, IL-1, IL-17) peaked during demyelination in whole brain homogenates, while most markers declined during remyelination, TNF- and IL-17 remained elevated and IL-1 expression increased further

[DOI] [PMC free article] [PubMed] [Google Scholar] Sorce S, Krause KH
