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Inactivation of GPX4 in cells triggers the accumulation of lipid peroxides, leading to ferroptosis 28

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Specifically, PROTAC 82 degraded ATR with a DC 50 value of 22.9 nM and a D max value of 76% in MV-4-11 cells and showed the ability to inhibit cell proliferation of several AML cells (IC 50 values ranging from 0.111.3 M)