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To view digital features for this article, go to Introduction For several decades, N -acetylcysteine (NAC) has been used in clinical practice worldwide in a variety of indications: as a mucolytic, in acetaminophen intoxication, doxorubicin-induced cardiotoxicity and in other cardiovascular, respiratory and psychiatric disorders [1]

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Following the estimation and determination of active sites using a grid box measuring 30 30 30 along the x, y, and Z axes, the grid box was centered at the precise center of the active site